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Fact Sheet
Pharmacogenomics is a growing area of genomic medicine that uses a person’s genomic information to help healthcare providers select the medications and dosages that are predicted to work best in each patient.
… on data obtained from people with predominantly European ancestry. This means that pharmacogenomic tests may miss …
Event
The NHGRI and NCI held a pre-application webinar on May 15, 2020, for the Funding Opportunity Announcements (FOA) RFA-HG-20-001 and RFA-HG-20-002.
… (PRS) Methods and Analysis for Populations of Diverse Ancestry – Study Sites and Coordinating Center (U01 Clinical …
FAQ
On November 8-9, 2023, NHGRI sponsored its 15th Genomic Medicine meeting, Genomic Medicine XV: Genomics and Population Screening, in Bethesda MD. The following questions were answered during the meeting.
… ramifications of screening based on race and/or genetic ancestry? Recognizing that genetic variants track imperfectly … with self-identified race or background genetic ancestry, screening based on these factors will inevitably … of how people ascribe that have nothing to do with genetic ancestry and thus the two can't be conflated - …
News Release
Researchers identified 13 gene regions that influence cholesterol levels, some of which affected people differently if they are smokers or former smokers.
… or fat-like substance in the blood) in people of African ancestry. The researchers investigated whether smoking … a concerted effort to include many people of non-European ancestry since there are too few genomics studies of diverse … of lipids in terms of number of participants with African ancestry. This enabled researchers to find new gene regions …
Event
On January 25, 2023, the National Human Genome Research Institute will hold a roundtable on social and behavioral genomics.
… Matthews Social by Nature by Catherine Bliss Genetic ancestry testing among white nationalists: From identity … by Aaron Panofsky and Joan Donovan Getting genetic ancestry right for science and society by Anna C. F. Lewis, … How white nationalists mobilize genetics: From genetic ancestry and human biodiversity to counterscience and …
Research at NHGRI
CRGGH uses genomic tools to understand the pathobiology of metabolic disorders, including obesity, hypertension, diabetes, dyslipidemia, and kidney disease.
… Partial Test. Hum Hered, 73:73-83. 2012. [ PubMed ] Ancestry Shriner D, Tekola-Ayele F, Adeyemo A, Rotimi CN. … reconstruction of the 140,000 year history of modern human ancestry. Sci Rep 4:6055. 2014. [ PubMed ] Ancestry_2014.bed Ancestry_2014.bim Ancestry_2014.fam …
Educational Resources
Genetic testing is the use of a laboratory test to look for genetic variations associated with a disease.
… typically performed in the context of medical care, ancestry studies or forensics. In a medical setting, the …
News Release
More research must be done to understand the interactions of ancient genes with modern environments.
… sickness, but today Africans and people of African ancestry with these genetic mutations have a higher risk of … groups of people. The average percentage of African ancestry in the Americas varies widely: 87 percent in African … percent in Puerto Ricans, 7 percent in people with Mexican ancestry in Los Angeles and 4 percent in both Peruvians in …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… with particular emphasis on populations of African ancestry. The Africa America Diabetes Mellitus (AADM) study, … the association signals found in European and Asian ancestry populations; it has provided some of the earliest … the etiology of diabetes and related traits in African ancestry populations. CRGGH published the first GWAS for …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project developed patient-focused educational materials for the sickle cell community.