Search Results
Research Funding
Expired Funding Opportunity Announcements dating back to 1994, including Requests for Application, Program Announcements and Notices.
… Trial Not Allowed) RFA-HG-21-036 : Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) … Health (R01) PAR-13-231 : Phenotyping Embryonic Lethal Knockout Mice (R01) RFA-ES-16-003 : K22 BD2K Mentored Career …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2021.
… or Bioengineering and Biomedical Imaging Research (R01) 27 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Program … Consortium RFA-HG-21-036 - Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) RFA-HG-21-037 - Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… and the fish are far less costly to maintain than are mice. They multiply astonishingly quickly; a female may … Research paper. The CRISPR/Cas9 methodology works in mice, too, but it is more costly and takes far longer. Although mice actually reach sexual maturity earlier than zebrafish, …
Infographic
The X chromosome is part of sexual development and many other biological processes, including how some cats get their distinctive coat colors.
… The X chromosome plays a key function in aging. Mice with an XX genotype live longer than mice with XY, even if they have testes! The X chromosome …
Staff
Dr. Lisa Helbling Chadwick is a program director in Division of Extramural Research at the National Human Genome Research Institute.
… HF. Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval . Genetics , … influences on X chromosome choice in Xce heterozygous mice . Mamm Genome, 16(9):691-9. 2005. … Biography … …
Event
The 2018 meeting focused on KOMP's collaborations with various human disease gene discovery programs.
… Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2022.
… Emphasis Overview Scientific Areas of Emphasis Search 31 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Program … Phenotyping Consortium Website Fell et al. – “NIH Renews Knockout Mouse Project for 3rd Time” 32 Human Heredity & …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… place in the petri dish and in nonhuman organisms such as mice or zebrafish. Researchers rely on genome editing tools … A typical study might be to model human disease in mice by deleting or editing certain genes that are thought to …
About NHGRI
A timeline of notable events in the history of the National Human Genome Research Institute.
… unprecedented access to two private collections of knockout mice , providing valuable models for the study of human … laying the groundwork for a public, genome-wide library of knockout mice. October 26, 2005: The International HapMap …
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… development. Model systems, including genetically altered mice and in vitro cell and organ culture systems, are major …