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Fact Sheet
Early in the COVID-19 pandemic, researchers used state-of-the-art genomic sequencers to quickly sequence the SARS-CoV-2 virus.
… First, they separate the two strands of plasmid DNA. Then, RNA polymerase, the molecule that transcribes RNA from DNA, uses the spike protein gene to create a single …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… silencing or activation of messenger RNAs, long noncoding RNA and a host of other regulatory elements such as enhancers … neurodevelopmental disease and cancer. Center for Dynamic RNA Epitranscriptomes RM1 HG008935 Chuan He University of Chicago Chemical modifications on mammalian messenger RNA (mRNA) have recently been shown to play critical and …
Fact Sheet
Genomic research has been central to understanding and combating the SARS-CoV-2 (COVID-19) pandemic.
… virus, which is the pathogen that causes COVID-19, uses RNA as its genetic material. First, the PCR is converted from single-stranded RNA to double-stranded DNA in a process called reverse … of DNA copies corresponding to the SARS-CoV-2 viral RNA. … What do results mean for a COVID-19 PCR test?  A …
Staff
Dr. Daniel Gilchrist is a program director of Computational Genomics and Data Science in NHGRI's Division of Genome Science.
… GW, Burkholder A, Fargo DC, Adelman K. Stable pausing by RNA polymerase II provides an opportunity to target and … G, Fargo DC, Xie B, Gao Y, Li L, Adelman K. Pausing of RNA polymerase II disrupts DNA-specified nucleosome … S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. RNA polymerase is poised for activation across the genome. …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… in the lab. 4 With CRISPR, researchers create a short RNA  template that matches a target DNA sequence in the genome. Creating synthetic RNA sequences is much easier than engineering proteins as is those required for ZFNs and TALENs. Strands of RNA and DNA can bind to each other when they have matching …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… DNA, a synthetic type of DNA generated from messenger RNA, or mRNA, the molecule in the cell that takes information … how large numbers of genes are expressed as messenger RNA in a particular tissue, and how a cell's regulatory … the structural components, or building blocks, of DNA and RNA. A nucleotide consists of a base chemical - either …
News Release
Six new grants will support researchers for new computational approaches to search millions of genomic variants for disease susceptibility.
… not translated into proteins, they may be transcribed into RNA. Such RNA carries out various regulatory functions in a cell. The researchers have shown that disrupting RNA structure can lead to diseases in people, including an …
News Release
Genome: Unlocking Life's Code exhibition is going on tour after having completed a 14-month engagement at the Smithsonian's National Museum of Natural History.
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2022.
… Genotype-Tissue Expression Project (dGTEx) 20 Capturing RNA Sequence and Transcript Diversity, from Technology … Investigator-Initiated Highlights Smith et al. – “Enrichment Analyses Identify Shared Associations for 25 …
The Genomics Landscape
In the August 6, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about NHGRI's completion of the third phase of the ENCODE Project and how it reveals the most extensive catalog to date of candidate functional elements that may regulate the genes in the human and mouse genomes.
… genome function, the proteins that bind to DNA, and how RNA molecules interact to regulate gene expression. The …