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News Release
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.
… (which is commonly affected in cancers) in 44 percent of tumors. TP53 makes the p53 tumor suppressor protein, which … identified potential drug targets in 69 percent of the tumors evaluated. They found frequent mutations in the ERBB2 … responsible for cervical cancer - was found in bladder tumors. This suggests that viral infection can contribute to …
The Genomics Landscape
In the September 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, recaps the April 2023 virtual reunion of the leaders of the five genome-sequencing centers (G5), where they tell the untold story on how they ushered the Human Genome Project across the finish line in 2003.
… of a gene called GATA2, a gene known to be important for brain stem development. These findings demonstrate the …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… somatic mutations in PI3-kinase in endometrial tumors, thus uncovering previously unrecognized cohorts of … alterations that drive clinically aggressive endometrial tumors, and to understand their functional consequences. Dr. … the genetic and genomic alterations that drive solid tumors. In her previous position at Massachusetts General …
The Genomics Landscape
In the November 2024 issue of The Genomics Landscape, NHGRI Director Eric Green spotlights the History of Genomics Program, which has long worked to make various materials related to the history of genomics accessible to the public.
… cranial dysinnervation disorders (CCDDs), which affect brain development and can lead to issues associated with a …
News Release
The TCGA network describes uterine and bile duct cancer.
… uncontrolled cell growth that is the hallmark of malignant tumors. Last month, two publications from the TCGA network …
News Release
Researchers from The Cancer Genome Atlas Research Network identify novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma.
… identified, clinicians may be able to treat patients whose tumors have specific gene changes with drugs currently …
Staff
Dr. Sudre is an Associate Investigator in Dr. Philip Shaw's Neurobehavioral Clinical Research within the Social and Behavioral Research Branch
… at Carnegie Mellon University investigating how the human brain represents information. More specifically, they looked for semantic information in the brain while subjects perform several cognitive tasks and used … with machine learning techniques to classify different brain states. Previously, Dr. Sudre was part of the Human …
Genetic Disorders
Attention Deficit Hyperactivity Disorder (ADHD) is a neurological disorder that affects a person's ability to control their behavior and pay attention to tasks.
… are: 1) familial: ADHD often runs in families; 2) abnormal brain development; or 3) brain injuries occuring before, during or after birth. … Brain images of children with ADHD may show differences …
News Release
Researchers funded by NHGRI’s Genome Technology Program include a wide range of investigators with a variety of scientific expertise.
… , to probe intricate cellular details of the mouse brain and how immune cells change in different environments …
Staff
Dr. Philip Shaw was an investigator in the Social and Behavioral Research Branch at the National Human Genome Research Institute.
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… environmental factors that influence the development of brain and behavior. A focus of his work was the most common … factors in shaping the developmental trajectories of brain and behavior. The program focused on one of the most … to behavioral processes that can be mapped directly onto brain structure and function. The work linking brain …