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News Release
NHGRI researchers have developed the Families Sharing Health Assessment and Risk Evaluation (SHARE) workbook, which helps people use their family history to assess their risk for heart disease, diabetes, breast cancer and colorectal cancer.
… to assess their risk for heart disease, diabetes, breast cancer and colorectal cancer. Since 2012, Laura Koehly, Ph.D., and her research … trees associated with heart disease, diabetes, breast cancer and colorectal cancer. Definitions of each disease and …
Staff
Dr. Julie Segre is chief and a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… tools to track hospital-acquired infections of multi-drug resistant organisms, including the NIH's recent … reconstructed a polymicrobial outbreak of multi-drug resistant Acinetobacter baumannii that swept through the … overall fitness. MGS's long-term goal is to create a drug strategy that capitalizes on the bacterium's loss of …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease … editing as a treatment for disease. Many diseases from cancer to asthma have genetic bases. Through the application … commercial labs around the world. Treatments for HIV and cancer are being tested in clinical trials in patients. In …
Genetic Disorders
WAGR syndrome is a genetic condition caused by a deletion of genes located on chromosome 11, often causing eye problems and increased risk of cancer in babies.
… and are at high risk for developing certain types of cancer, and mental disability. … WAGR syndrome is a rare … and are at high risk for developing certain types of cancer, and mental disability. The term "WAGR" stands for the … condition: (W)ilms' Tumor, the most common form of kidney cancer in children. (A)niridia, some or complete absence of …
News Release
Researchers identified regions of the genome associated with skin color variation in some African populations, furthering skin disease and cancer research.
… opening new avenues for research on skin diseases and cancer in all populations. … These findings may help … from these regions is thought to reduce skin damage and cancer. In contrast, lighter pigmentation of people in … the DNA loci and associated genes that play roles in skin cancer susceptibility and the effects of UV radiation." In …
Staff
Dr. Rongling Li is an epidemiologist and program director in the Division of Genomic Medicine at the National Human Genome Research Institute.
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… medical records, gene-environment interactions, gene-drug interactions … Dr. Rongling Li is an epidemiologist and …
News Release
NHGRI researchers have identified new genes associated with the Erdheim-Chester disease (ECD) and some possible new therapies.
… V600E gene mutations, which is sometimes seen in colon cancer, lung cancer, thyroid cancer, brain tumors and some blood cancers. … the most common treatment for ECD has been interferon , a drug that interferes with the division of cancer cells and …
Staff
Dr. Joshua Denny is the head of the NHGRI Precision Health Informatics Section and Chief Executive Officer of the National Institutes of Health’s All of Us Research Program.
… Program, and UK Biobank to better understand disease and drug response. Prior to joining the NIH in 2020, Josh was a … N. B., Dai, Q., … Denny, J. C. (2015). Validating drug repurposing signals using electronic health records: A case study of metformin associated with reduced cancer mortality. Journal of the American Medical Informatics …
Profile
Dr. Joan Bailey-Wilson, who retired in September 2022, looks back on her 42-year career as a scientist and reflects on the rapid growth of the genomics field.
… Early in my career, I was involved in breast cancer risk modeling that led to Mary-Claire King discovering … with Henry Lynch to find genes associated with colorectal cancer.  At the time, there was huge controversy on the existence of genes that contributed to breast cancer and colorectal cancer. In the 1970s and 1980s, many …
Staff
Sangeetha Raghavan is a Senior Licensing and Patenting Manager in NHGRI's Technology Transfer Office.
… in wide ranging areas of biologics, diagnostics, drug delivery, therapeutics, medical devices, plant … Patented Technology, Licensing, biologics, diagnostics, drug delivery, therapeutics, medical devices, plant …