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… hub and spoke design • Focus on real -world health care delivery • Coordinating Center – Logistics planning – Support … PGx testing for antiplatelet therapy • Reduce adverse drug side effects Diversity in ancestry 72,147 IGNITE …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… account a person's genetic information regarding specific drug receptors and how drugs are transported and metabolized … goal of pharmacogenetics is to create an individualized drug therapy that allows for the best choice and dose of drugs. One example is the breast cancer drug trastuzumab (Herceptin). This therapy works only for …
Office of Genomic Data Science
NHGRI is committed to increasing the availability of educational and research opportunities in computational genomics and data science (CGDS).
… burdened by disparities in health status and health care delivery, including racial and ethnic minority groups, …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… hope was based on the success of imatinib (Gleevec), a drug that was specifically designed to treat a blood cancer … in many CML patients. Unfortunately, the one-target, one-drug approach has not held up for most other types of cancer. … pathways and the genetic profiles of particular tumors, drug developers might be able to focus their attention on …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… Such high-throughput screening has identified thousands of drug candidates over the past 10 years but has resulted in …
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… authorized for use in the United States by the Food and Drug Administration (FDA) are mRNA vaccines. … Fact Sheet … …
Genetic Disorders
Severe Combined Immunodeficiency is a severe, genetic condition of the immune system.
… evaluating insertion profiles of standard and novel gene delivery methods. A goal of this work is to find ways to …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
… to genomics: " pinpoint gene editing ," " a cancer drug's broad swipe ," and " gene therapy triumph ." Nature's …
News Release
The Genetics/Genomics Competency Center now includes a new section on pharmacogenetics and pharmacogenomics.
… genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular … advanced resources for pharmacists implementing specific drug/gene pairs, such as CPIC guidelines, are also available. …
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… and through descriptions of best practices for the delivery of genomic medicine. 2) Education: Provide education … ACMG has entered into an agreement with the US Food and Drug AdministrationÕs Center for Devices and Radiologic … genetic services across the lifespan and across healthcare delivery systems. At the time of the rollout of the ACA and …