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Staff
Dr. Lisa Helbling Chadwick is a program director in Division of Extramural Research at the National Human Genome Research Institute. ​
… evaluation of candidate variants, and the development of high-throughput genomic technologies related to gene expression or …
Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
… the design and selection of overgo probes optimized for high-throughput comparative mapping. SubmiRine A software package …
News Release
In a new large-scale genetic analysis, National Institutes of Health (NIH) scientists have found set of small RNA molecules, called microRNAs, in human pancreatic cells that are strongly associated with type 2 diabetes.
… Using next-generation DNA sequencing, a fast and high-throughput method for sequencing nucleic acids (like DNA and … too much sugar circulating in the bloodstream. Prolonged high blood sugar levels can lead to heart disease, kidney …
Policies and Guidance
Broad data sharing promotes maximum public benefit from federally funded genomics research. NHGRI supports the broadest appropriate genomic data sharing with timely data release through widely accessible data repositories. These repositories may be open access (unrestricted) or, if more appropriate, controlled access.
… molecular data produced by array-based technologies or high-throughput sequencing technologies. Data pertinent to the …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… research. Dr. Shawn Burgess' lab at NHGRI has developed a high-throughput pipeline that can create multiple, simultaneous …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… – has gone largely unfulfilled. What is needed are facile, high-throughput methods for generating libraries of human cells … the genome and epigenome. These platforms will enable high-precision engineering of both the nuclear and …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… occupied the forefront of research innovation by using high-risk screens to identify major modifiers of primary … to identify candidate therapeutic compounds via high-throughput screens, its Therapeutics for Rare and Neglected … in establishment of a natural history study to identify screening criteria and biomarkers for use in gauging …
Staff
Barbara Thomas is a scientific review officer for the Center for Inherited Disease Research (CIDR).
… (CIDR) , a trans-NIH program that provides access to high throughput genotyping and next-generation sequencing services … and decision making through the CIDR Board of Governors, high-level oversight of project management, and data sharing …
Staff
Dr. Stephanie Morris is a program director in NHGRI's Division of Genome Sciences.
… in 2019. She manages a portfolio of grants focused on high-throughput genomic technology development and functional …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… recombination is that it is inaccurate and has a high rate of error when the injected DNA fragments insert … J., Xu, L. S., Gallardo, V., . . . Burgess, S. M. (2015). High-throughput gene targeting and phenotyping in zebrafish using …