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News Release
By considering mixed genetic lineages, NHGRI researchers demonstrated that previously inferred links between a genomic variant that helps digest lactose and traits such as a person’s height and cholesterol level may not be valid.
… are related to different traits helps researchers estimate polygenic risk scores and may give clues about a person’s ability to respond …
The Genomics Landscape
In the August 2019 edition of The Genomics Landscape, NHGRI Director Eric Green recognizes the recipients for the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor given by the U.S. Government to outstanding scientists and engineers who are beginning their independent research careers.
… The meeting, entitled Genomic Medicine XII: Genomics and Risk Prediction , assessed the biomedical landscape related to polygenic risk scores and how it may be improved. It also aimed to identify …
News Release
When it comes to Attention-Deficit/Hyperactivity Disorder (ADHD), genetics do make an impact.
… significance alone, but together they increase the genetic risk for certain symptoms of the disorder. The more ADHD … Adding them all up can provide you with a 'genetic risk score' (called the polygenic risk score) that can predict the chances of having …
Careers and Training
NHGRI provides funding to support the development and implementation of modules aimed at providing healthcare professionals with genomic medicine training.
… nurses. … Project Title: Preparing providers to integrate polygenic risk scores into clinical care Lead Investigator for Project: …
Event
The NHGRI and NCI held a pre-application webinar on May 15, 2020, for the Funding Opportunity Announcements (FOA) RFA-HG-20-001 and RFA-HG-20-002.
… (FOA) RFA-HG-20-001 and RFA-HG-20-002 entitled "Polygenic Risk Score (PRS) Methods and Analysis for Populations of …
The Genomics Landscape
In the January 5, 2023 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., talks about how artificial intelligence and machine learning are becoming omnipresent throughout NHGRI and in genomics.
… these metabolic changes can impact physical traits such as risk of disease or drug toxicity. In this paper (Surendren et … ML is being used for improving the methods for calculating polygenic risk scores , which reflect an individual's genetic risk for a …
Fact Sheet
Eugenics is the scientifically erroneous and immoral theory of “racial improvement” and “planned breeding,”
… to terminate pregnancies where the fetus is at heightened risk for genetic disorders, such as Down Syndrome and spina … bifida. The emergence of statistical techniques, such as polygenic risk scores, that can estimate risks for more genetically complex …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… $38 million over five years to establish and support the Polygenic Risk MEthods in Diverse populations (PRIMED) Consortium. … robust methods for improving the way that polygenic risk scores (PRS) can be used to predict disease in ancestrally …
National Advisory Council for Human Genome Research
The Director's Report Related documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in May 2020.
… PAR-20-101 - Genomic Expert Curation Panels (U24) 18 Polygenic Risk Score Diversity Consortium RFA-HG-20-001 - Polygenic Risk Score (PRS) Methods and Analysis for …
Genomics and Medicine
Starting in 2019, the American Journal of Human Genetics has published an annual feature identifying ten key advances in applying genomic information to clinical care that were reported in the previous 12 months of published literature. The Genomic Medicine Working Group has authored these reviews, based on its broader effort to identify notable accomplishments in genomic medicine on a monthly basis. From this larger set of published accomplishments, the working group has continued to select ten papers annually to be highlighted as the most significant.
… management but is less likely in underrepresented patients Polygenic risk scores and family history are independent indicators of …