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News Release
Researchers sequence the genomes of healthy participants, then analyze the data to find presumed, mutations that might lead to a genetic condition.
Health FAQ
Discuss these questions with your doctor or health care provider.
… Education Project welcomes your feedback about the sickle cell disease gene therapy resources. Please email your … your general understanding of gene therapy for sickle cell disease. We encourage you to use these educational … a plan for the treatments you are taking for your sickle cell disease. For example, if you are taking hydroxyurea, you …
Educational Resources
A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) technique.
… Primer … A primer is a short, single-stranded DNA sequence used in the polymerase chain … (PCR) … A primer, as related to genomics, is a short single-stranded DNA fragment used in certain laboratory … and other experimental processes. … A primer is a short, single-stranded DNA sequence used in the polymerase chain …
Research Funding
MorPhiC aims to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene by using in-vitro multicellular systems.
… and Validation Centers will undertake applicant-proposed analyses of the data in order to characterize its quality and …
News Release
Researchers analyzing human, fly, and worm genomes have found these species have key genomic processes in common, reflecting their shared ancestry.
… patterns and regulatory proteins that help determine cell fate often share common features. Investigators also … species use protein packaging to compact DNA into the cell nucleus and to regulate genome function by controlling … These additional papers report studies involving deeper analyses within one or more species, methods development and …
Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
Research at NHGRI
NHGRI center focused on computationally intensive approaches to analyze large-scale genomic data and identifying genetic contributions to human disease.
Educational Resources
A germ line is the sex cells (eggs and sperm) that are used by sexually reproducing organisms to pass on genes from generation to generation.
… to generation. … Germ Line, Sexual Reproduction, Cell Biology … Germ line refers to the sex cells (eggs and …
Educational Resources
Metagenomics is the study of the structure and function of entire nucleotide sequences isolated and analyzed from all the organisms (typically microbes) in a bulk sample.
News Release
NIH researchers demonstrated that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1.
… gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1 … occurs when a faulty housekeeping gene fails to remove cell waste, like lipids and cholesterol. The accumulation of … severe NPC1 symptoms. Credit: Darryl Leja, NGHRI.  With a single injection, mice showed improvements in motor …