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News Release
Funding to advance understanding of RNA biology and development of RNA-based technologies
… Amherst, will focus on synthesizing long RNA molecules using a microfluidics platform, which consists of … which fluids are moved or stored. Scientists use long RNA molecules to probe genomic pathways and develop new drugs, … RNA to develop technologies and therapeutics such as small interfering RNA-based drugs and messenger RNA-based …
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… organisms that breathe underwater, develop from an egg so small it is barely visible to the naked eye and are striped … uses genome-editing technology to intentionally introduce small insertions or deletions in genes, making them …
Fact Sheets
Genomics is the study of all of a person's genes (the genome), including interactions of those genes with each other and with the person's environment.
… direct the activities of nearly all living organisms. DNA molecules are made of two twisting, paired strands, often … a ribosome, and the information is used to link together small molecules called amino acids in the right order to form … of a disease. The disease-causing change may be as small as the substitution, deletion, or addition of a single …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… gene to a specific point in the cell's DNA. AAVs are small viruses that infect humans but do not cause disease. A … Mir341 that codes for a microRNA molecule. MicroRNAs are small, non-coding RNA molecules involved in the regulation of gene expression. When …
News Release
Micro-sized technologies are among the approaches researchers will use to develop high quality, low cost DNA sequencing technology.
… the pore. Nanopores used in DNA sequencing are extremely small, perhaps only about 2 nanometers wide, and come in … of physical DNA. Microfluidics can be used to capture small amounts of liquid in hair-thin channels and wells. … Akeson, Ph.D. Investigators plan to sequence single DNA molecules by using a nanopore device comprised of a sensor …
News Release
NHGRI researchers have produced the first end-to-end DNA sequence of a human chromosome. The results show that generating a precise, base-by-base sequence of a human chromosome is now possible, and will enable researchers to produce a complete sequence of the human genome.
… the human genome. Until now, the pieces were too small, and there was no way to put the hardest parts of the … the human genome. Until now, the pieces were too small, and there was no way to put the hardest parts of the … small pieces of DNA, they used a method that leaves DNA molecules largely intact. These large DNA molecules were then …
Research at NHGRI
The Metabolic Medicine Branch houses clinical and laboratory research programs that focus on the development of new therapies for patients with genetic disorders.
… dysfunction and create mouse models to test novel small molecules to treat genetic skeletal diseases. They use …
Research at NHGRI
The Genetics and Molecular Biology Branch uses genomic technologies to study the human genome and other organisms and disease mechanisms.
… investigators have discovered disease genes and identified small molecules to treat inherited diseases and malignancies. …
Profile
Reflecting on his NIH career, Dr. Smith recounts his journey from researcher to program director in a conversation with NHGRI science writer Sonja Soo, Ph.D. He looks ahead to a retirement filled with traveling, spending time with friends and family, playing pickleball and brewing ale.
… Our team also managed the congressionally mandated small business program referred to by the Small Business Administration as “America’s Seed Fund.” … is a growing area with tremendous opportunities for small businesses. The NHGRI small business program has …