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Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… in basic research. Editing the genomes of yeast, bacteria, mice, zebrafish, and other organisms that scientists commonly … and price. … [1] Capecchi, M. R. (2005). Gene targeting in mice: functional analysis of the mammalian genome for the …
Staff
Dr. Francis Collins is a senior investigator in Center for Precision Health Research.
… the disease seen in HGPS patients. Specifically, these mice exhibit progressive loss of vascular smooth muscle cells … prevented the onset of cardiovascular disease in young mice but also reduced the progression of the cardiovascular defects upon treatment of older mice. This research complemented other data in support of a …
Staff
Dr. Michael Erdos is an Associate Investigator in the Molecular Genetics Section of the Center for Precision Health Research.
… successful at reducing the cardiovascular defects in young mice. In addition, it improved the cardiovascular histopathology when administered to older mice. This work supported the first clinical trial … C/T DNA base editors are capable of systemic delivery in mice and can achieve 8-30% mutation correction in critical …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… also the genomes of important research organisms, such as mice, C. elegans and zebrafish. Throughout the Human Genome …
The Genomics Landscape
In the January 2019 edition of The Genomics Landscape, NHGRI Director Dr. Eric Green honors NIAMS Director, Stephen Katz, M.D., Ph.D.
… Genomics Research Elevated Hormone Flags Liver Problems in Mice with Methylmalonic Acidemia Zooming in on Meiosis …
News Release
ENCODE program directors in the Division of Genome Sciences turned to Reddit to answer questions from the Reddit community.
… in the mouse, we got what looked like viable 'normal' mice. We were expecting the mice to die or have some sort of selective phenotype we could …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… factor SOX10  result in neural crest stem cell defects in mice that accurately model enteric nervous system … gene therapy can increase the lifespan of NPC1 mutant mice, and also improve neuronal and liver abnormalities. … CP. Systemic AAV9 gene therapy improves the lifespan of mice with Niemann-Pick disease, type C1. Hum Mol Genet . …
Event
On November 5-9, 2024, the National Human Genome Research Institute (NHGRI) will participate in the ASHG Annual Meeting - the world's largest human genetics and genomics meeting and exposition.  The annual meeting provides a forum for the presentation and discussion of cutting-edge science in all areas of human genetics.Â
… Platform talk: Rescue of Proteus syndrome lethality in mice with prenatal miransertib treatment Speaker, Shaima Raji …
News Release
NIH researchers have developed and released an innovative software tool, called Verso, to assemble truly complete (i.e., gapless) genome sequences from a variety of species. The software makes the process of assembling complete genome sequences more affordable and accessible.
… sequences of species commonly used in research, such as mice, fruit flies and zebrafish, improving their usefulness …
Staff
Dr. Shurjo Sen is a program director in NHGRI's Division of Genome Sciences who manages a portfolio of grants focused upon genomic data sciences, and is particularly interested in transitioning genomics from a centralized data repository model to cloud-based collaborative science.
… Iliev ID, Belkaid Y, Trinchieri G, Rehermann B. Laboratory mice born to wild mice have natural microbiota and model human immune responses …