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Educational Resources
A marker is a DNA sequence with a known physical location on a chromosome. Markers can help link an inherited disease with the responsible genes.
Educational Resources
Northern blot is a laboratory technique used to detect a specific RNA sequence in a blood or tissue sample.
Educational Resources
Ancestry-informative markers are sets of polymorphisms for a DNA sequence found in different frequencies between populations from different geographical regions.
The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… were difficult to “read out” completely using the DNA-sequencing methods available at that time. In addition, the … Information. These efforts have included additional DNA sequencing by new and different methods to close gaps and … from NHLBI’s Intramural Research Program. Applications for next year’s fellowship are due by November 1. … In …
Educational Resources
Epigenetics is an emerging field of science that studies heritable changes caused by the activation and deactivation of genes without any change in the underlying DNA sequence of the organism.
… cell to daughter cell during cell division or from one generation to the next. The collection of all epigenetic changes in a genome is …
Educational Resources
A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli).
… E. coli). … Cloning, Bacteria, Bioengineering, DNA Sequencing, Base Pair, Chromosomes … A bacterial artificial … E. coli). BACs are often used in connection with DNA sequencing. Segments of an organism's DNA, ranging from … the BAC DNA, which can then be isolated and used in sequencing DNA. … A bacterial artificial chromosome (BAC) is …
Outreach
The Genome: Unlocking Life's Code exhibition celebrates the 10th anniversary of the initial sequencing of the human genome.
… their families, and global populations; and what the next decade holds in terms of genomic advances. A Spectrum of … exhibition celebrates the 10th anniversary of the initial sequencing of the human genome. … Human Genome Sequencing, Smithsonian Exhibition, Genomics 101, Genomics …
News Release
NIH researchers have sequenced the whole genome of a dog native to Sardinia, Italy, and discovered in it clues about the migration of humans to the area.
… and guard humans as they have for hundreds of years. By sequencing the whole genome of a Fonni's Dog and comparing it … Dogs sets it apart as a unique pure breed. The researchers next will explore regions of the Fonni's Dog genome to … the migration of humans to the area. … Sardinian dog sequencing, human migration, Fonni's Dogs, Sardinian's …
About Genomics
Resources for understanding the first truly complete sequence of the Y chromosome, the final human chromosome to be fully sequenced.
News Release
The goat has contributed its DNA to a new method for high-quality, low-cost genome reconstruction, one that will be useful for reading human and other genomes.
… researchers used a variety of methods, including PacBio sequencing , which was released in 2011. Dr. Phillippy and … of folded DNA in the nucleus of each cell. "PacBio sequencing, optical mapping and Hi-C have all been used for … They are also investigating emerging "nanopore" genome sequencing methods for the real-time diagnosis of human …