Search Results
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that … to cancer susceptibility syndromes and to the development of various aggressive cancers, including prostate, … with both population scientists and clinicians to define gene profiles that offer predictability in terms of cancer …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… Methylation … Methylation is a chemical modification of DNA and other molecules that may be retained as cells … make more cells. … Methylation is a chemical modification of DNA and other molecules that may be retained as cells … make more cells. When found in DNA, methylation can alter gene expression. In this process, chemical tags called methyl …
Genomics and Medicine
The NHGRI Genomic Medicine Working Group has compiled a list of interesting advances.
… Genomic Medicine Working Group  (GMWG) compiles a list of interesting advances and helpful educational resources in … Milestones In Medicine, Clinical Implementation Of Genomics, Pharmacogenomics, Oncology Sequencing, … Group has compiled a list of interesting advances. … Genomics and Medicine …
Educational Resources
Population genomics is the application of genomic technologies to understand populations of organisms.
… Population Genomics … Population genomics is the application of genomic technologies to understand populations of organisms. … Gene, Genome, Genetic Variation, Allele, Founder Effect, …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. … diseases that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have … about 85 percent of their genes! By changing a single gene or multiple genes in a mouse, scientists can observe how …
Educational Resources
A genotype is an individual's collection of genes.
… Genotype … A genotype is an individual's collection of genes. … Genotype, Genes, DNA Sequence, Phenotype … A genotype is a scoring of the type of variant present at a given location (i.e., a … BB, Bb, bb could be used to represent a given variant in a gene. Genotypes can also be represented by the actual DNA …
Educational Resources
A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest.
… Physical Map … A physical map of a chromosome or a genome that shows the physical locations … genes and other DNA sequences of interest. … Chromosome, Gene, Deoxyribonucleic Acid (DNA), Positional Cloning … A physical map, as related to genomics, is a graphical representation of physical locations …
Fact Sheets
Genome-wide association studies involve scanning markers across the genomes of many people to find genetic variations associated with a particular disease​.
… studies involve scanning markers across the genomes of many people to find genetic variations associated with a … involves rapidly scanning markers across the complete sets of DNA, or genomes, of many people to find genetic variations … form of blindness is associated with variation in the gene for complement factor H, which produces a protein …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… Sheena Faherty Ph.D. … In the basement of a three-story brick building on the main campus of the … But this wee creature is making big waves in the sea of genomics research. The zebrafish is a powerhouse tool that … of NHGRI's Zebrafish Core. "They can request any single gene or multiple genes in a pathway they want knocked out," …
Clinical Research
The CLINSEQ® Study seeks to learn about the role that your genes play in your health.
… by getting a DNA sample from you, sequencing most or all of your genes, and comparing that to what we know about your … Free CAT scan to detect coronary artery disease.  Finding gene changes that are important to your health and/or the … Institutes of Health researchers has turned traditional genomics research on its head. Trans-NIH Study Explores …