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Event
On February 16, 2023, the National Human Genome Research Institute (NHGRI) held a follow-up working group consultation after the 14th Genomic Medicine meeting, Genomic Medicine XIV: Genomic Learning Healthcare Systems.
Event
NHGRI and NICHD program staff will hold a pre-application interactive Q&A webinar for the Developmental Genotype-Tissue Expression Project funding opportunities and answer questions from prospective applicants.
… ELSI research is required. Would the BPC need to advise on brain dissection strategies, or other tissue selection … determine the best strategy. It depends on the number of brain sections that are dissected. It is expected that the BPC would have provisions to be able to do the expert brain dissections and be able to provide the tissues to the …
Staff
Dr. Edward Giniger is an adjunct investigator in NHGRI's Genetics and Molecular Biology Branch.
… Information processing in the brain is done by specialized neural circuits. Every neuron … almost certainly acts in construction of the human brain and nervous system. … Giniger, E. How do Rho family … in mushroom body neurons of the Drosophila central brain. J. Neurosci . 31:10451-62. 2011. [PubMed] Gates, M.A., …
Staff
Dr. Eggerton Campbell is a senior licensing and patenting manager in the Technology Transfer Office at the National Human Genome Research Institute.
… nucleic acid amplification (PCR), detection of tumors/cancer via mutations, recombinant polypeptides, human …
Media Availability
New research provides a better understanding of some of the genetic and cellular changes in pathways and processes involved in Autism Spectrum Disorder.
… Synapses are the spaces between nerve cells over which brain messages must travel. Mutations in synaptic genes and … on and off, and the formation of neural connections in the brain. Transcription. Instructions embedded in genes must be … can affect a wide range of important processes in the brain, from controlling gene activity to transmitting …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… biological pathways and the genetic profiles of particular tumors, drug developers might be able to focus their … likely to repair the pathways affected in their particular tumors. … How do biological pathways work? … What are some …
Staff
Dr. Heidi Parker is an Associate Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch, NHGRI.
… and complex trait mapping and genomic analysis of canine tumors. The primary goal of Dr. Parker’s research is to use … and shared regions of dysregulation with human bladder tumors . BMC Cancer 24;20(1):251, 2020. Parker HG*, Whitaker …
Staff
Dr. Dan Kastner is an NIH Distinguished Investigator in Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… of mice and examined regulatory DNA and gene activity in brain and other tissue. They found that more than 80 percent … parent, they found that expression in 95 genes in the brain depended more on being inherited from one parent than … unexpectedly discovered that for thousands of genes in the brain, there was a slightly greater expression of genes …
Staff
Dr. Acosta is a board-certified pediatric neurologist with the NIH Undiagnosed Diseases Program's GM1 gene therapy trial.
… using interspecies comparisons of clinical outcomes and brain connectivity changes using r-fMRI techniques. As … our intervention using traditional and novel techniques in brain MRI- including structural, magnetic resonance … (NCT02461420); and the “Autoimmune Brain Disorders Program” lead by Dr. Gena Mooneyham at NIMH. …