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The Genomics Landscape
NHGRI medical genetics training programs provide an array of education opportunities
… Equity Fellowship Program in partnership with the Food and Drug Administration’s (FDA’s) Office of Minority Health and …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… hope was based on the success of imatinib (Gleevec), a drug that was specifically designed to treat a blood cancer … in many CML patients. Unfortunately, the one-target, one-drug approach has not held up for most other types of cancer. … pathways and the genetic profiles of particular tumors, drug developers might be able to focus their attention on …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… Such high-throughput screening has identified thousands of drug candidates over the past 10 years but has resulted in …
News Release
The Genetics/Genomics Competency Center now includes a new section on pharmacogenetics and pharmacogenomics.
… genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular … advanced resources for pharmacists implementing specific drug/gene pairs, such as CPIC guidelines, are also available. …
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… authorized for use in the United States by the Food and Drug Administration (FDA) are mRNA vaccines. … Fact Sheet … …
Genetic Disorders
Crohn's disease is a chronic inflammatory disorder of the bowel, usually diagnosed in people between the ages of 20 - 30.
… such as abdominal pain, diarrhea and rectal bleeding. Drug therapy for Crohn's disease includes: Anti-inflammation … system suprressors, such as 6-mercaptopurine or a related drug, azothioprine. Infliximab (Remicade), a drug that is the first of a group of medications that blocks …
News Release
NHGRI hosted a CRISPR "Ask Me Anything" with Jennifer Doudna, Ph.D., reaching 10.5 million people worldwide.
Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… curtail a gene's activities. Researchers identified two drug-metabolizing variants tied to three TPMT alleles. The …
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… – two conditions where finding safe and effective drug treatments have been difficult. Because there are few … makeup helps determine how they will respond to certain drug treatments. In pharmacogenomics, information about a … makeup helps determine how they will respond to certain drug treatments. These projects build upon the first phase of …