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NHGRI science writer Prabarna Ganguly spoke with Segre about her research career, what makes microbes so complex and her roles in science policy and anti-harassment campaigns.
… issue of containment of both pandemic threats and multi-drug-resistant organisms. How would we detect and then … in tracking hospital-acquired infections of multi-drug-resistant organisms. Over the 20 years that Segre has …
The Genomics Landscape
In the July 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., emphasizes the importance of the Technology Transfer Office and its mission to manage all the legal negotiations that help to protect federally funded research from being unduly exploited, while also giving that research avenues to reach patients through the commercialization of promising advances.
… search by scientific area. … Genomics Research Gene therapy for rare eye disease safe but lacks efficacy in early …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
… inflammation and wound healing. The work also identified a drug that targets an important feedback loop controlled by … the researchers treated the patients with a JAK-inhibiting drug called ruxolitinib, the patients’ rashes and ulcers …
News Release
Over the last 20 years, three families have been unknowingly linked to one another by an unknown illness. Researchers at the National Human Genome Research Institute (NHGRI) and other organizations have now identified the cause of the illness, a new disease called CRIA syndrome. The results of their work were published on Dec. 11 in the journal Nature.
… had little effect on the patients, one biological drug called tocilizumab did. Tocilizumab, a drug that suppresses the immune system, reduced the severity …
Genetic Disorders
Spinal muscular atrophy is a group of inherited disorders that cause progressive muscle degeneration and weakness.
… valproic acid, hydroxyurea, and riluzole. At present gene therapy - replacing the altered genes with a normal version ? …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… milestone for progeria research, as the U.S. Food and Drug Administration approved the first treatment for progeria in November 2020, a drug called lonafarnib. The drug therapy provides some life extension, but it is not a cure. …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… to survive childhood. But today, due to preventive drug treatment, improved medical care and aggressive … antibiotics, pain management and blood transfusions. A new drug treatment, hydroxyurea, which is an anti-tumor drug, … is a risky procedure with many complications. Gene Therapy Offers Promise of a Cure: Researchers are …
The Genomics Landscape
In the May 2019 edition of The Genomics Landscape, NHGRI Director Eric Green recaps activities from National DNA Day 2019.
… for RNA ENCODE is the latest Amazon Public Data Set Gene Therapy Restores Immunity in Infants with Rare Immunodeficiency Disease Anti-Inflammatory Drug Halts Strokes in Children with Rare Disease Personalized … Kids First and KOMP2 Pilot Project NIH Streamlines Gene Therapy Oversight and Charts a Course for Considering …
Research Funding
The following are research areas of interest that have been identified by the participating NIH institutes and centers (ICs). Program Officer contact information is also included.
… voice, speech, and language. … The National Institute on Drug Abuse (NIDA) is interested in research that focuses on … disorder trajectory, treatment recommendations, and drug-drug interactions in diverse patients. Research related … system tissue; development and/or application of gene therapy and gene editing technologies for neurogenetic …
Educational Resources
Single nucleotide polymorphisms (SNPs) are a type of polymorphism involving variation of a single base pair.
… if and how SNPs in a genome influence health, disease, drug response and other traits. … Single nucleotide …