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The Human Genome Project changed traditional understandings of how and why scientific research is conducted. It was, however, not without its detractors. Early in 1990, there was an effort to stop funding for the nascent Human Genome Project, in the form of a letter writing campaign.
… It was, however, not without its detractors. … Early in 1990, as the Human Genome Project was ramping up, … role in keeping the Human Genome Project on track in those early days , Dr. Jordan responded to each of these letters, … is conducted. It was, however, not without its detractors. Early in 1990, there was an effort to stop funding for the …
Funding Opportunities
The NHGRI Genomic Innovator Awards support highly innovative work by early career genomics investigators who are part of consortia or other team-science efforts. All awardees work on critical, emerging topics in genomics. These awards recognize creative endeavors with great potential to accelerate future genomics research.
… Genomic Innovator Awards support highly innovative work by early career genomics investigators who are part of consortia … Genomic Innovator Awards support highly innovative work by early career genomics investigators who are part of consortia … Genomic Innovator Awards support highly innovative work by early career genomics investigators who are part of consortia …
Staff
Dr. Heidi Sofia served as a program director in the Division of Genomic Medicine at the National Human Genome Research Institute from 2010-2023.
… NHGRI in 2010 as part of the team responsible for The Cancer Genome Atlas (TCGA) initiative in cancer genomics, jointly managed by NHGRI and the National Cancer Institute (NCI). TCGA was instrumental in setting the …
Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… associated with body overgrowth and increased risk of cancer; Prader-Willi syndrome, associated with poor muscle … changes can lead to uncontrolled growth, a hallmark of cancer, or to a failure of the immune system to destroy … treating patients with the drug temozolomide, which kills cancer cells by adding methyl groups to DNA. In some cases, …
Educational Resources
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… the system that regulates cell division. … BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … A tumor suppressor … Such mutations may contribute to the development of a cancer. … A tumor suppressor gene directs the production of a …
Educational Resources
Apoptosis is the process of programmed cell death.
… death. … Programmed Cell Death, Development, DNA Repair, Cancer, Tumor, Cell Division … Apoptosis is the process of programmed cell death. It is used during early development to eliminate unwanted cells; for example, … beyond repair. Apoptosis also plays a role in preventing cancer. If apoptosis is for some reason prevented, it can …
Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… of multiple genes and environmental factors. … Genes, Cancer, Heart Disease, Gene-environment Interactions … A … genetic diseases include heart disease, diabetes, and cancer. … A complex disease is caused by the interaction of …
Educational Resources
A mutagen is a chemical or physical phenomenon, such as ionizing radiation, that promotes errors in DNA replication.
… DNA replication. … Mutagen, DNA Mutation, DNA Replication, Cancer … A mutagen is a chemical or physical agent capable of …
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… challenge health care providers face in treating prostate cancer is distinguishing the aggressive, potentially … way to identify a specific subgroup of prostate cancer tumors with a known treatment option," said Elaine … focuses on BRCA2 mutations, which are associated with breast and ovarian cancer, but also increase men's risk for …
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
… the number of copies of a gene sequence. … DNA Sequence, Cancer, PCR, Polymerase Chain Reaction, Laboratory Experiment … an increase in the number of copies of a gene in a genome. Cancer cells, for example, sometimes produce multiple copies …