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The Genomics Landscape
In the July 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes the inaugural class of the ASHG-NHGRI Genomics and Public Service Fellowship Program.
… and breadth of the scientific, clinical, and societal elements of human genetics and genomics, as well as to …
News Release
NIH has awarded grants of more than $28 million aimed at deciphering the language of how and when genes are turned on and off.
… said Mike Pazin, Ph.D., a program director in the Functional Analysis Program in NHGRI's Division of Genome … role in disease. Such regions likely contain gene-control elements that are altered by these variants, which increase … disease. "Knowing the interconnections of these regulatory elements is critical for understanding the genomic basis of …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… libraries of human cells bearing mutant sequence elements and for assessing these libraries to determine each … and scalable technologies to generate, and assess the functional impact of, variants in human genes. In the first … relevance, enabling comparisons between each variant's functional effects and the effects of known pathogenic or …
Research Funding
Frequently Asked Questions for IGVF RFAs: RFA-HG-20-043, RFA-HG-20-044, RFA-HG-20-045, RFA-HG-20-046, RFA-HG-20-047
… be well-justified. Can applicants propose to perform functional validation studies within their Mapping Centers? No. Functional validation and characterization are out of scope for this initiative. Candidate functional elements identified by Mapping Centers may be tested in later …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… initial catalog of yeast genes and to predict a new set of functional elements that play a role in regulating genome activity, not … NHGRI programs such as ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism Encyclopedia of DNA …
News Release
NHGRI researchers identified 59 genes or gene regions linked to canine athletics.
Staff
Dr. Elisabeth F. Heuston is a molecular biology and bioinformatics Staff Scientist with the Center for Research on Genomics and Global Health (CRGGH).
… of mentor Dr. Robert J. Arceci, Dr. Heuston used in vitro functional assays and in vivo rodent models to identify … aims to create a catalogue of functionally-defined genomic elements that influence the pathophysiology of …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… expression, as well as surrogate markers of regulatory elements, in different cell fates or cell states. They use the gene expression and functional element data to construct gene regulatory network … methods with catalogs of genomic data to understand what elements are controlling what genes, in what cell types. The …
News Release
NHGRI hosted two Pathway to Independance awardees and supported 18 additional investigators at institutions nationwide.
… of Michigan, Ann Arbor, Global Discovery and Validation of Functional Regulatory Elements James Bentley Brown, Ph.D., University of … National Laboratory, Berkeley, Nonparametric Methods for Functional and Translational Genomics Christopher Cassa, …
Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… in cells from other lineages. NHGRI’s ENCyclopedia Of DNA Elements (ENCODE) Project was developed to identify all functional elements in the human genome, including epigenetic … LA, Garrett LJ, Elnitski L, Gallagher PG, Bodine DM. Functional analysis of a novel cis-acting regulatory region …