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- Genetic Architecture of Complex Traits1
- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… Cellular Signatures (LINCS). Discovering such cell responses will improve scientists' understanding of cell pathways and aid in the development of new therapies for … second phase of LINCS is to optimize the combinations of cell types, perturbations and measurements of cellular …
News Release
By considering mixed genetic lineages, NHGRI researchers demonstrated that previously inferred links between a genomic variant that helps digest lactose and traits such as a person’s height and cholesterol level may not be valid.
The Genomics Landscape
In the June 2020 edition of The Genomics Landscape, NHGRI Director Eric Green details NHGRI's new Diversity in Genomics Workforce Initiative.
… gene-editing therapy to cure an individual with sickle cell disease. This has been heralded as a landmark moment for … the use of gene editing for treating inherited diseases. Sickle cell disease is a group of disorders that affects …
Talking Glossary
Chromosomes are threadlike structures made of protein and a single molecule of DNA that serve to carry the genomic information from cell to cell.
… of DNA that serve to carry the genomic information from cell to cell. … Chromosomes are threadlike structures made of protein … of DNA that serve to carry the genomic information from cell to cell. In plants and animals (including humans), …
Talking Glossary
A gamete is a reproductive cell of an animal or plant.
… Gamete … A gamete is a reproductive cell of an animal or plant. … A gamete is a reproductive cell of an animal or plant. In animals, female gametes are … called sperm. Ova and sperm are haploid cells, with each cell carrying only one copy of each chromosome. During …
Educational Resources
Mendelian inheritance refers to certain patterns of how traits are passed from parents to offspring.
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
Fact Sheets
Chromosomes are thread-like structures located inside the nucleus of animal and plant cells.
… Scientists gave this name to chromosomes because they are cell structures, or bodies, that are strongly stained by some … For example, if all of the DNA molecules in a single human cell were unwound from their histones and placed end-to-end, … produce new cells to replace old, worn-out cells. During cell division, it is essential that DNA remains intact and …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… agents and their effects on the development of a cell’s normal state. In addition, LINCS developed a resource … “signatures” that reflect the responses that different cell types show under different conditions. LINCS was based … cellular characteristics, behavior, and/or function of a cell. In the past, most research studies designed to …