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Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… form spool-like structures that enable DNA's very long molecules to be wound up neatly into chromosomes inside the … inherited from the mother and one from the father. For a small number of genes, only the copy from the mother gets …
News Release
NIH researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children.
… patients. They discovered a problem in the processing of a small protein, ubiquitin, which is critical to the regulation … of many other proteins in the body, including immune molecules. In the affected children, the inability to remove the ubiquitin proteins from various molecules resulted in an increased production of chemical …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in May 2022.
… Genome Technology Development Website and Registration 21 Small Business Program Small Business Program Website NIH-funded Startups are …
Educational Resources
Mitochondria are membrane-bound cell organelles (mitochondrion, singular) that generate most of the chemical energy needed to power the cell's biochemical reactions.
… energy produced by the mitochondria is stored in a small molecule called adenosine triphosphate (ATP). Mitochondria contain their own small chromosomes. Generally, mitochondria, and therefore …
Fact Sheets
A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
… in genes like BRCA1 and BRCA2 . The chip consists of a small glass plate encased in plastic. Some companies … the two complementary strands of DNA into single-stranded molecules. The next step is to cut the long strands of DNA …
Genomics Teaching Tool
An activity that demonstrates how DNA can be isolated from a strawberry using common household items.
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… EGFR gene explain the dramatic clinical responses of non-small cell lung cancer patients to gefitinib, a small molecule inhibitor of EGFR. Upon joining NHGRI in 2006, … in EGFR explain the dramatic clinical responses of non-small cell lung cancer patients to gefitinib, a small …
The Genomics Landscape
In the September 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, recaps the April 2023 virtual reunion of the leaders of the five genome-sequencing centers (G5), where they tell the untold story on how they ushered the Human Genome Project across the finish line in 2003.
… genome sequencing began to ramp up, it was decided that a small group of leaders from the largest genome-sequencing … research involving recombinant or synthetic nucleic acid molecules Funding Opportunities SBIR/STTR Commercialization … allowed and clinical trial required NIH, CDC and FDA for small business innovation research grant applications NIH and …
News Release
Doctors and researchers reunite with patient who received gene therapy for GM1 gangliosidosis.
… gene makes an important enzyme that helps to break down molecules within cells. Without a functioning version of the GLB1 gene, molecules accumulate and wreak havoc on the cells of the … in the patient’s DNA. Each rare disorder affects a small population, but when considered together, they affect …
The Genomics Landscape
In the July 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes the inaugural class of the ASHG-NHGRI Genomics and Public Service Fellowship Program.
… still uncovering new functions of this versatile class of molecules. In recent years, the genomics community has been … Amherst and will focus on synthesizing long RNA molecules using a microfluidics platform. The other project … Centers for Health (NARCH)     NHGRI and NIH News How a small group of scientists and educators are enhancing the …