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Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… form spool-like structures that enable DNA's very long molecules to be wound up neatly into chromosomes inside the … inherited from the mother and one from the father. For a small number of genes, only the copy from the mother gets …
News Release
NIH researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children.
… patients. They discovered a problem in the processing of a small protein, ubiquitin, which is critical to the regulation … of many other proteins in the body, including immune molecules. In the affected children, the inability to remove the ubiquitin proteins from various molecules resulted in an increased production of chemical …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in May 2022.
… Genome Technology Development Website and Registration 21 Small Business Program Small Business Program Website NIH-funded Startups are …
Educational Resources
Mitochondria are membrane-bound cell organelles (mitochondrion, singular) that generate most of the chemical energy needed to power the cell's biochemical reactions.
… energy produced by the mitochondria is stored in a small molecule called adenosine triphosphate (ATP). Mitochondria contain their own small chromosomes. Generally, mitochondria, and therefore …
Fact Sheets
A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
… in genes like BRCA1 and BRCA2 . The chip consists of a small glass plate encased in plastic. Some companies … the two complementary strands of DNA into single-stranded molecules. The next step is to cut the long strands of DNA …
Genomics Teaching Tool
An activity that demonstrates how DNA can be isolated from a strawberry using common household items.
The Genomics Landscape
In the September 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, recaps the April 2023 virtual reunion of the leaders of the five genome-sequencing centers (G5), where they tell the untold story on how they ushered the Human Genome Project across the finish line in 2003.
… genome sequencing began to ramp up, it was decided that a small group of leaders from the largest genome-sequencing … research involving recombinant or synthetic nucleic acid molecules Funding Opportunities SBIR/STTR Commercialization … allowed and clinical trial required NIH, CDC and FDA for small business innovation research grant applications NIH and …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… EGFR gene explain the dramatic clinical responses of non-small cell lung cancer patients to gefitinib, a small molecule inhibitor of EGFR. Upon joining NHGRI in 2006, … in EGFR explain the dramatic clinical responses of non-small cell lung cancer patients to gefitinib, a small …
News Release
Doctors and researchers reunite with patient who received gene therapy for GM1 gangliosidosis.
… gene makes an important enzyme that helps to break down molecules within cells. Without a functioning version of the GLB1 gene, molecules accumulate and wreak havoc on the cells of the … in the patient’s DNA. Each rare disorder affects a small population, but when considered together, they affect …
The Genomics Landscape
In the July 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes the inaugural class of the ASHG-NHGRI Genomics and Public Service Fellowship Program.
… still uncovering new functions of this versatile class of molecules. In recent years, the genomics community has been … Amherst and will focus on synthesizing long RNA molecules using a microfluidics platform. The other project … Centers for Health (NARCH)     NHGRI and NIH News How a small group of scientists and educators are enhancing the …