Search Results
The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… were difficult to “read out” completely using the DNA-sequencing methods available at that time. In addition, the … Information. These efforts have included additional DNA sequencing by new and different methods to close gaps and … and basic research scientists. A Human Reference Genome Sequencing Center at the University of California, Santa Cruz …
Educational Resources
Epigenetics is an emerging field of science that studies heritable changes caused by the activation and deactivation of genes without any change in the underlying DNA sequence of the organism.
Educational Resources
A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli).
… E. coli). … Cloning, Bacteria, Bioengineering, DNA Sequencing, Base Pair, Chromosomes … A bacterial artificial … E. coli). BACs are often used in connection with DNA sequencing. Segments of an organism's DNA, ranging from … the BAC DNA, which can then be isolated and used in sequencing DNA. … A bacterial artificial chromosome (BAC) is …
Outreach
The Genome: Unlocking Life's Code exhibition celebrates the 10th anniversary of the initial sequencing of the human genome.
… exhibition celebrates the 10th anniversary of the initial sequencing of the human genome. … Human Genome Sequencing, Smithsonian Exhibition, Genomics 101, Genomics … exhibition celebrates the 10th anniversary of the initial sequencing of the human genome. … Outreach …
News Release
North Asians may be more closely related to Eastern and Northern Europeans than previously thought.
… Institute (NHGRI), made the connection by comparing the whole-genome sequences of 175 ethnic Mongolians to existing … This includes a number of coordinated large scale sequencing projects such as the HapMap and 1000 Genomes … previously thought. … genetic diversity, ancestry, genome sequencing, Lawrence Brody … North Asians may be more closely …
About Genomics
Resources for understanding the first truly complete sequence of the Y chromosome, the final human chromosome to be fully sequenced.
News Release
The goat has contributed its DNA to a new method for high-quality, low-cost genome reconstruction, one that will be useful for reading human and other genomes.
… researchers used a variety of methods, including PacBio sequencing , which was released in 2011. Dr. Phillippy and … of folded DNA in the nucleus of each cell. "PacBio sequencing, optical mapping and Hi-C have all been used for … They are also investigating emerging "nanopore" genome sequencing methods for the real-time diagnosis of human …
News Release
Evaluating genetic features of inherited diseases by sequencing the genetic code helps with the cost and time challenges in medical practice.
… all potential genetic features of inherited diseases by sequencing the genetic code is a powerful solution to … get in there and start touching patient data." Through new sequencing technologies, data is accumulating in an … M.D., Ph.D. But how do we make sure that using genome sequencing for disease diagnosis, treatment and prevention …
Educational Resources
A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.
News Release
Researchers developed a technique that will aid in a more accurate reconstruction of human genomes.
… a genome from the much smaller pieces of DNA that sequencing machines are able to read, much like putting … Trio binning takes advantage of the newest generation of sequencing technology that can "read" much longer areas of … a suspected genetic disease, the clinician will order DNA sequencing for their patient to identify where in the genome …