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Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… replacing it or disrupting it with an artificial piece of DNA. … Knocking out the activity of a gene provides valuable … may cause or contribute to disease in humans. Examples of research in which knockout mice have been useful include … researchers use one of two methods to insert artificial DNA into the chromosomes contained in the nuclei of ES cells. …
Media Advisory
On April 25, 2023, NHGRI will host a symposium to commemorate two special milestones: the 20th anniversary of the Human Genome Project’s completion and the 70th anniversary of the discovery of the DNA double helix.
… For Immediate Release … On National DNA Day, the National Human Genome Research Institute (NHGRI), part of the National Institutes … and the 70th anniversary of the discovery of the DNA double helix. The event is free and open to the public. …
News Release
NHGRI researchers and colleagues are calling for health disparities research that focuses on the microbiome.
… Mjoseth … Researchers at NIH's National Human Genome Research Institute (NHGRI) and their colleagues* are calling for health disparities research that focuses on the microbiome. Health disparities … and homelands despite decades of health disparities research . The role of the microbiome on ethnic and racial …
Research at NHGRI
The Center for Precision Health Research, formerly Medical Genomics and Metabolic Genetics Branch, studies how health and disease are related to genetic, genomic and metabolic variation.
… The investigators in the Center for Precision Health Research (CPHR) develop and evaluate cutting edge genomic and … healthcare. … The Center for Precision Health Research (CPHR) was established in 2021 as a research group within NHGRI’s Intramural Research Program to …
About NHGRI
The National Advisory Council for Human Genome Research provides expert advice on genetics, genomics research, training and programs to NHGRI and the NIH.
… The National Advisory Council for Human Genome Research (NACHGR) advises the Department of Health and Human … Institutes of Health (NIH), and the National Human Genome Research Institute (NHGRI), on genetics, genomic research, training and programs related to the human genome …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… , scientists have set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how … are similar. Investigators from two National Human Genome Research Institute (NHGRI)-funded programs, the Encyclopedia …
Funded Research
The Advancing Genomic Medicine Research (AGMR) program stimulates innovation and advance understanding of when, where and how best to implement the use of genomic information and technologies in clinical care.
… (ARDI): Advancing Genomic Medicine through rare diseases research in Africa Sean David University of Chicago … Gallagher University of California, San Francisco Toward DNA Sequencing as a Primary Newborn Screen for Treatable … … Historically, NHGRI has largely funded genomic medicine research through multi-disciplinary consortia. The AGMR …
Talking Glossary
Un codón de terminación es una secuencia de tres nucleótidos (un trinucleótido) en el DNA o el ARN mensajero (ARNm) que señaliza una parada en la sÃntesis proteica de la célula.
… una secuencia de tres nucleótidos (un trinucleótido) en el DNA o el ARN mensajero (ARNm) que señaliza una parada en la … is a sequence of three nucleotides (a trinucleotide) in DNA or messenger RNA (mRNA) that signals a halt to protein … una secuencia de tres nucleótidos (un trinucleótido) en el DNA o el ARN mensajero (ARNm) que señaliza una parada en la …
Fact Sheets
Polymerase chain reaction (PCR) is a technique used to "amplify" small segments of DNA.
… (PCR) is a technique used to "amplify" small segments of DNA. … Sometimes called "molecular photocopying," the … technique used to "amplify" - copy - small segments of DNA. Because significant amounts of a sample of DNA are necessary for molecular and genetic analyses, studies …
Educational Resources
Ribonucleic acid (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded.
… (RNA) … Ribonucleic acid (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded. … Cell, Genetic Code, Deoxyribonucleic Acid (DNA), Protein, Uracil, Adenine, Cytosine, Guanine, Messenger …