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News Release
A team of NIH-funded researchers have generated the first complete chromosome sequences from non-human primates.
… DNA sequences. These sequences are much more challenging for scientists to characterize, and studying repetitive DNA … has only become possible in recent years due to new DNA sequencing technologies and analysis methods. These … among the primate Y chromosomes is their length. For example, the Y chromosome from the Sumatran orangutan is …
News Release
NHGRI will fund a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases.
… Institute (NHGRI), part of NIH, today launched the Centers for Common Disease Genomics (CCDG), which will use genome … CMG researchers have also developed and disseminated tools that enable scientists to rapidly discover such genes. … find genes that cause Mendelian diseases, with a focus on novel genes, she said. NHGRI, pending available funds, will …
Educational Resources
A restriction enzyme is an enzyme isolated from bacteria that cuts DNA molecules at specific sequences.
… at specific sequences. … Bacteria, Deoxyribonucleic Acid (DNA), Enzyme, Genetic Engineering, Recombinant DNA …
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… Randy Chandler is an associate investigator in the Organic Acid Research (OAR) Section of the Metabolic Medicine Branch … focused on adeno-associated virus (AAV) gene therapy for the treatment of hemophilia A, a genetically inherited … has focused on the efficacy of gene therapy as a treatment for rare genetic disorders, such as methylmalonic acidemia …
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… Last week, we started a new fiscal year for the federal government. As is often the case, we began … at the NIH funding process as well as provide tips and tools for successful grant writing; this session will take … sequence to public databases weekly, as large-scale DNA sequencing had advanced substantially. At that time, it …
Educational Resources
Transcription is the process of making an RNA copy of a gene sequence.
… of a gene sequence. … Cell, Cytoplasm, Deoxyribonucleic Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), … to the cell cytoplasm (watery interior), where it is used for synthesizing the encoded protein. … Transcription is the …
Educational Resources
Cloning is the process of making identical copies of an organism, cell, or DNA sequence.
… isolating and copying a particular DNA segment of interest for further study. … Cloning is the process of making …
Clinical Research
This team-based clinical service is provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
… NHGRI to Intramural Investigators employing exome/genome sequencing to accomplish their research goals. The SGFS will annotate de-identified research exome/genome data for the presence of possible actionable secondary variants. … NHGRI to Intramural Investigators employing exome/genome sequencing. ​ … DNA Sequencing, Exam Sequencing, Genome …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… The Centers for Common Disease Genomics (CCDG) are a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and … studies for common disease. Develop resources, informatics tools, and innovative approaches and technologies for …
News Release
Researchers from NHGRI, Oxford University and other National Institutes of Health centers have developed and tested a new method to predict hospital-acquired infections involving five other important pathogens.
… "But is there a way we can accurately predict your risk for acquiring a hospital-acquired infection just by using … hospital data?" Hospital staff usually test patients for infections when they start showing symptoms, but that … Health Service (NHS) hospitals in Oxfordshire, U.K. for at least 48 hours between 2011 and 2015. The NHS, which …