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Talking Glossary

Next-generation DNA sequencing (abbreviated NGS) refers to the use of technologies for sequencing DNA that became available shortly after the completion of the Human Genome Project (which relied on the first-generation method of Sanger sequencing).

… Next-Generation DNA Sequencing … Next-generation DNA sequencing (abbreviated NGS) … Project (which relied on the first-generation method of Sanger sequencing). … DNA sequencing establishes the order of … Project (which relied on the first-generation method of Sanger sequencing). Faster and cheaper than their …

News Release

New study challenges gold standard for validating DNA sequencing results

A new study by researchers at the National Human Genome Research Institute (NHGRI) is challenging traditional practices for validating DNA sequencing results.

… is challenging traditional practices for validating DNA sequencing results. The research suggests that newer, faster, … methods are as accurate - and perhaps more accurate - than Sanger sequencing, a time-tested technique that is typically … the online edition of the journal Clinical Chemistry . The Sanger sequencing method burst onto the genetics scene in the …

News Release

Dr. Bob Blakesley, director of the NISC sequencing group, rides off into the sunset

NIH lost a key member of its broader genomics team when Robert Blakesley, Ph.D., director of the NISC sequencing group at NIH, retired on Dec. 31, 2015.

… 31 retirement of Robert Blakesley, Ph.D., director of the sequencing group at the NIH Intramural Sequencing Center … 57 million DNA sequence reads for 76 researchers using the Sanger dideoxy sequencing method. That figure has spiked in … medical diagnostics. "That hooked me. At the time, Fred Sanger and Wally Gilbert (British and American biochemists, …

Educational Resources

Shotgun Sequencing

Shotgun sequencing is a laboratory technique for determining the DNA sequence of an organism's genome.

… Shotgun Sequencing … Shotgun sequencing is a laboratory technique for determining the DNA … an organism's genome. … Deoxyribonucleic Acid (DNA), DNA Sequencing, Genome, Human Genome Project … Shotgun sequencing …

15 Ways Genomics Influences Our World

DNA Sequencing

Advances in genomics are reducing the cost of genome sequencing by a million-fold.

… Advances in genomics are reducing the cost of genome sequencing by a million-fold. … Did you know that your genome … DNA, including a million-fold reduction in the cost for sequencing a human genome. Continually improving the accuracy … sequences. As a result, we now have multiple methods for sequencing DNA quickly and inexpensively (see videos in …

Educational Resources

DNA Sequencing

DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule.

… DNA Sequencing … DNA sequencing is a laboratory technique used to determine the … … Adenine, Cytosine, Guanine, Thymine, ACGT, DNA, DNA Sequencing … DNA sequencing refers to the general laboratory …

Fact Sheets

DNA Sequencing Costs: Data

Data used to estimate the cost of sequencing the human genome over time since the Human Genome Project.

… (NHGRI) has tracked the costs associated with DNA sequencing performed at the sequencing centers funded by the … the time when the sequencing centers transitioned from Sanger-based (dideoxy chain termination sequencing) to … 2007 represent the costs of generating DNA sequence using Sanger-based chemistries and capillary-based instruments …

Research Funding

Genome Sequencing Program Coordinating Center

Coordinates activities across the Genome Sequencing Program components

… The National Human Genome Research Institute's Genome Sequencing Program Coordinating Center (GSPCC) was funded in 2016 to coordinate activities across the Genome Sequencing Program components. … The GSPCC has both … and administrative activities including: Tracking genome sequencing and analysis costs; data production and …

Fact Sheets

The Cost of Sequencing a Human Genome

Estimated cost of sequencing the human genome over time since the Human Genome Project.

… have led to substantial reductions in the cost of genome sequencing. The underlying costs associated with different methods and strategies for sequencing genomes are of great interest because they … scrutiny and attention have been given to genome-sequencing costs and how they are calculated since the …

Research Funding

Genome Sequencing Program Analysis Centers

Funded in 2016 to harmonize, access, and analyze the data produced by the sequencing centers.

… The Genome Sequencing Program Analysis Centers (GSPACs) were funded in … to harmonize, access, and analyze the data produced by the sequencing centers. The GSPACs undertake novel, … … Participants … Grantees … Program Staff … Genome Sequencing Program Analysis Centers … Funded in 2016 to …