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- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
… Stem Cell … A stem cell is a cell with the potential to form … of the different cell types found in the body. When stem cells divide, they can form more stem cells or other cells that perform specialized functions. Embryonic stem cells have the potential to form a complete …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body. … Called induced pluripotent stem cells (iPSCs), this technique opens the doors to medical …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… its make-up is different among cell types, even among cells that are similar. Investigators from two National Human … the genome what to do - among three types of cells: mouse embryonic stem (ES) cells, embryonic fibroblasts and hematopoietic …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… called Hydractinia, does so because it produces germ cells, which are precursors to eggs and sperm, nonstop … reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ … similar to gonads in species like humans. During human embryonic development, a small pool of germ cells that will …
Educational Resources
A somatic cell is any cell of the body except sperm and egg cells.
… Somatic Cells … A somatic cell is any cell of the body except sperm and egg cells. … Cell, Chromosome, Diploid, Mutation, Germ Line … Somatic cells are the cells in the body other than sperm and egg …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… of 8,500 knockouts of mouse genes, in the form of embryonic stem (ES) cells. He is now working to implement The Knockout Mouse …
Educational Resources
A cell cycle is a series of events that takes place in a cell as it grows and divides.
… mitosis, and completes its division. The resulting cells, known as daughter cells, each enter their own interphase and begin a new round …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and … rod-like structures. These structures cause red blood cells to become stiff, assuming a sickle shape. Their shape causes these red blood cells to pile up, causing blockages and damaging vital organs …
Educational Resources
The cell membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside environment.
… membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside … … Plasma Membrane, Proteins, Glycoproteins, Lipid Bilayer, Cells … The cell membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside …
Genetic Disorders
Holoprosencephaly is a disorder caused by the failure of the the embryonic forebrain to sufficiently divide into the double lobes of the cerebral hemispheres.
… disorder caused by the failure of the prosencephalon (the embryonic forebrain) to sufficiently divide into the double … is a disorder caused by the failure of the the embryonic forebrain to sufficiently divide into the double … … Holoprosencephaly, HPE, Birth Defect, Prosencephalon, Embryonic Forebrain, Facial Defects, Alobar, Semilobar, …