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A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… the aggressive, potentially life-threatening tumors from curable, less aggressive tumors. … Researchers with the National Human Genome Research … a specific genomic signature of some aggressive prostate tumors, which may help health care providers pinpoint …
Genetic Disorders
Colon cancer is a malignant tumor of the large intestine that affects both men and women.
News Release
NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.
… set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer. … More than 10,000 Tumors Analyzed "This project is the culmination of more than … with unprecedented understanding of how, where and why tumors arise in humans, enabling better informed clinical …
News Release
An ancient, sexually transmitted dog cancer may provide insights into human cancers because of the similarities in the dog and human immune systems.
… unhealthy dog tumor genomes, they found mutations in the tumors' genes that are involved in the ability of the host's … as dangerous outsiders. "The immune systems in dogs with tumors had lost the ability to recognize cancer cells because … it successfully for more than five thousand years." "Most tumors employ strategies to avoid destruction by the immune …
Genetic Disorders
Dercum disease is a rare condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of middle age.
… condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of … by multiple, painful fatty lipomas (benign, fatty tumors) that occur chiefly in post-menopausal, obese women of … condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of …
Media Availability
TCGA researchers have found that chromophobe renal cell carcinoma stems partly from gene alterations in the mitochondria, the cell's energy supplier.
… examining the entire genomes of 50 of the 66 ChRCC tumors studied, a high number for a rare cancer. The study … DNA. This led researchers to discover that ChRCC tumors favor a different energy-generating process than that … in the mitochondria, the cell's energy supplier. … Kidney tumors, chromophobe renal cell carcinoma, ChRCC, The Cancer …
News Release
NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
… around the gene known as ZNF154 that is unique to tumors." Dr. Elnitski is head of the Genomic Functional … identified the methylation mark using DNA taken from solid tumors. "No one in my group slept the night after that … methylation marks in the mixture. Knowing that tumors often shed DNA into the bloodstream, they calculated …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… the most common type of brain tumor in adults, but these tumors are difficult to treat. The research team noticed that … folded, causing genetic neighborhoods to merge. Within the tumors that have a mutated IDH gene, scientists found that …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.