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- Developmental Genotype-Tissue Expression (dGTEx)1
- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Clinical Genome (ClinGen) Resource1
- Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
News Release
Researchers funded by NHGRI’s Genome Technology Program include a wide range of investigators with a variety of scientific expertise.
… help scientists advance key areas such as: understanding gene regulation and genome function; synthesizing nucleic … investigating mRNA have to choose between looking at the expression of a few select genes in a whole tissue or looking … the second approach provides a more comprehensive look at gene expression. For Fei Chen, Ph.D. , professor at the Broad …
News Release
NIH expands its Encyclopedia of DNA Elements Project, which is creating a fundamental genomics resource scientists to study human health and disease.
… and develop methods to determine how they contribute to gene regulation in a variety of cell types and model systems. … functional elements in healthy individuals; but gene expression may be regulated differently in people that …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… on cellular phenotypes, protein make-up and gene expression readouts in cell lines. Broad Institute of the … genes. Each perturbation will produce about 1,000 gene-expression readouts. By the project's end, Dr. Golub …
The Genomics Landscape
In the October 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., introduces us to new scientific director Charles Rotimi, Ph.D., his background and prior accomplishments.
… map of the functions of regulatory and non-regulatory gene elements. The IGVF consortium includes five components: … five years to support the Developmental Genotype-Tissue Expression (dGTEx) project, with funding from NHGRI, the … therapeutic genes to muscles NIH will expand existing gene expression resources to include developmental tissues …
Staff
Dr. Temesgen Fufa is a program director in NHGRI's Division of Genome Sciences.
… in 2022. He has a long-standing interest to understand how gene regulation plays a role in development and human … Cancer Institute in the Laboratory of Receptor Biology and Gene Expression. Dr. Fufa completed his postdoctoral research at …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… to a stratified random-sampling strategy based on gene density and level of non-exonic conservation. The … and bottom 50 percent - along each of two axes: 1) gene density and 2) level of non-exonic conservation with … detail, the stratification criteria were as follows: Gene density: The gene density score of a region was the …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… Novartis) have created their own LINCS-related low-cost gene-profiling technologies, and Novartis has even leveraged … for Non-Human Primate Developmental Genotype-Tissue Expression project (NHP dGTEx) — July 9 NIH webinar on … Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) project New investigators to promote …
Staff
Dr. Daniel Gilchrist is a program director of Computational Genomics and Data Science in NHGRI's Division of Genome Science.
… Health Sciences, where he studied mechanisms of gene regulation. Dr. Gilchrist received a B.S. in biology … pervasive effects of Pol II pausing on stimulus-responsive gene networks. Genes Dev , 26:933-44. 2012. [ PubMed ] … K. NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. …
The Genomics Landscape
In 2022, The Genomics Landscape spotlighted genomic data sharing each month in a series of entries. This page contains a collection of each of those entries.
… published: February 3, 2022  The Genotype-Tissue Expression (GTEx) project generated NHGRI’s most frequently … studying the relationship between genomic variation and gene expression. Because GTEx data can be shared for general …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… for making dramatic, coordinated changes to extensive gene loci in the form of Big DNAs of 50-1000 kb, which enable … will require accurate manipulation of DNA sequences and gene expression as well as interrogation of the functional …