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News Release
Researchers at NHGRI have discovered an immune mechanism in humans that perceives threats and was found only in plants.
… putting the safety pin back in place and quelling the inflammation and fever. The guard mechanism in plants and … important to providing insights into processes like inflammation that, to date, are still not well understood in …
News Release
Daniel Kastner, M.D., Ph.D., Scientific Director for the Intramural Research Program at the National Human Genome Research Institute (NHGRI) recognized for his pioneering work on the genomics of autoinflammatory diseases.
… NOMID manifests as a disorder that causes persistent inflammation and tissue damage, affecting the nervous system, … , which occur when patients have seemingly unprovoked inflammation, but without the antibodies and T-cells that are …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… Regulatory Programs Of CD4+ T Lymphocyte Populations In Inflammation In vivo inflammation model, mouse T helper cells Jeremy Luban, M.D. …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
… version of a protein called STAT4, which regulates inflammation and wound healing. The work also identified a … these four patients, creating a positive feedback loop of inflammation and impaired wound-healing that worsens over …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… protein was somehow acting as an attractant that promoted inflammation, a necessary component of wound healing. "When … tissue regeneration and wound healing by regulating inflammation and cell proliferation . npj Regenerative …
Clinical Research
A study with the goal of finding the genetic cause of familial Mediterranean fever (FMF) and several novel and undiagnosed causes of autoinflammatory disease.
… by seemingly unprovoked episodes of systemic or localized inflammation, without evidence of infection and without the … How to Bake Cookies  Demystifying Medicine 2017: Inflammation: One Gene at a Time … Lab Team Brynja …
Fact Sheets
Genome-wide association studies involve scanning markers across the genomes of many people to find genetic variations associated with a particular disease​.
… factor H, which produces a protein involved in regulating inflammation. Few previously thought that inflammation might contribute so significantly to this type …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… fellow in Dr. O'Shea's lab in the Molecular Immunology and Inflammation Branch. The study was performed in collaboration … immune system mistakenly attacks its own cells, causing inflammation. Different tissues are affected in different …
15 Ways Genomics Influences Our World
Genomics is ending diagnostic odysseys for patients with rare diseases.
… a mutation in the gene NLRP3,  which causes abnormal inflammation throughout the body. After only one treatment with a medicine to dampen this inflammation, Zarko's symptoms improved. Just like Sonia and …
News Release
Researchers from the NHGRI-funded Impact of Genomic Variation on Function Consortium are exploring how genomic variation affects genome function.
… in female versus male mice and in mice with and without inflammation. The specific variants being studied were … To simulate different environmental conditions such as inflammation and cellular stress, the researchers expose the …