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Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
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… tissues of oxygen (called vaso-occlusive crises), pain and tiredness. Researchers do not know how gene therapy … for sickle cell have different benefits, such as decreased pain and lower levels of sickled hemoglobin. Any conditions … hemoglobin, less hemolysis and little to no vaso-occlusive pain events . Those who participate in gene therapy may also …
News Release
NHGRI researchers investigated the Behcet's disease using Illumina's Immunochip.
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… human biology.” Most studies on senescence are related to chronic inflammation, cancer and age-related diseases. … senescent cells stay senescent, and these cells cause chronic inflammation and induce aging in adjacent cells. From … in human cells. “Most studies on senescence are related to chronic inflammation, cancer and age-related diseases,” said …
News Release
NHGRI researchers have developed the Families Sharing Health Assessment and Risk Evaluation (SHARE) workbook, which helps people use their family history to assess their risk for heart disease, diabetes, breast cancer and colorectal cancer.
… Americans experience a disproportionately high number of chronic diseases compared to other racial and ethnic groups … R., Carthron, D., Corbie-Smith, G., & Eng, E. (2020). Chronic Disease Among African American Families: A Systematic Scoping Review . Preventing Chronic Disease , 17, E167. Gee, G. C., & Payne-Sturges, D. …
Research Funding
The Multi-Omics for Health and Disease Consortium aims to advance the application of multi-omic technologies to study health and disease in ancestrally diverse populations.
… Zachariah, Ali Gharavi Columbia University Multi-Omics for Chronic Kidney Disease Disease Study Site Louise Laurent*, …
The Genomics Landscape
In the July 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., emphasizes the importance of the Technology Transfer Office and its mission to manage all the legal negotiations that help to protect federally funded research from being unduly exploited, while also giving that research avenues to reach patients through the commercialization of promising advances.
… data were used in studies covering a variety of topics: chronic complex diseases, type 2 diabetes, epigenomics, …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… in lung tissue damage that causes acute chest syndrome, pain episodes, stroke and priapism (painful, prolonged … 50 years. Treatments for sickle cell include antibiotics, pain management and blood transfusions. A new drug treatment, …
News Release
Researchers have discovered that FGF21 is elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia.
… reach terminal stages of renal failure, an expected chronic complication of MMA. Selecting which patients would …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
… The flow of urine can start and stop, be weak, or create pain or a burning feeling. Erection may hurt and there can be blood in the urine or semen. Pain may also occur in the back, hips or upper thighs. … is also used in later stages of prostate cancer to relieve pain. When the prostate cancer is in advanced stages, …