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- Genome Technology Program5
- Human Genome Reference Program (HGRP)1
- Impact of Genomic Variation on Function (IGVF) Consortium1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
News Release
Researchers funded by NHGRI’s Genome Technology Program include a wide range of investigators with a variety of scientific expertise.
… a variety of scientific expertise. … The advent of new DNA sequencing techniques has been a gamechanger in genomics. However, new genomic methods and technologies are still needed to advance basic and clinical … for each type of nucleotide. While the technique has high accuracy for DNA sequencing, directly reading RNA …
News Release
NHGRI convened geneticists, biologists, clinicians, bioinformatics specialists and more to provide expert advice on the future of its Genome Sequencing Program.
… provide expert advice on the future of its flagship Genome Sequencing Program (GSP). … The two-day meeting, titled, Future Opportunities for Genome Sequencing and Beyond: A Planning workshop for the National … clinic. In addition to the long-established Large-Scale Sequencing and Analysis Center (LSAC) program, the GSP now …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… grown louder due to faster, cheaper, and more efficient technologies. … While the popular media tends to focus on the … recombination is that it is inaccurate and has a high rate of error when the injected DNA fragments insert … Xu, L. S., Gallardo, V., . . . Burgess, S. M. (2015). High-throughput gene targeting and phenotyping in zebrafish using …
Research Funding
The Genome Sequencing Program uses genome sequencing to identify genes and genomic variants underlying human inherited disease.
… The Genome Sequencing Program is consists of the following centers … funding opportunity announcements. … The NHGRI Genome Sequencing Program (GSP) has evolved from NIH's participation … McGill University Len Pennacchio, Ph.D. Deputy of Genomic Technologies, DOE Joint Genome Institute & Senior Staff …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… Genomics (CCDG) are a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and … informatics tools, and innovative approaches and technologies for multiple disease research communities and … Common Disease Genomics … Collaborative large-scale genome sequencing effort to identify rare risk and protective …
News Release
A new study by researchers at the National Human Genome Research Institute (NHGRI) is challenging traditional practices for validating DNA sequencing results.
… is challenging traditional practices for validating DNA sequencing results. The research suggests that newer, faster, "next-generation" DNA sequencing (NGS) methods are as accurate - and perhaps more accurate - than Sanger sequencing, a time-tested technique that is typically used to …
Talking Glossary
Nanopore DNA sequencing is a laboratory technique for determining the exact sequence of nucleotides, or bases, in a DNA molecule.
… Nanopore DNA Sequencing … Nanopore DNA sequencing is a laboratory technique for determining the … nucleotides, or bases, in a DNA molecule. … Nanopore DNA sequencing is a laboratory technique for determining the …
News Release
Ten investigators will receive exome sequencing data as part of their clinical research projects at the NIH Clinical Center.
… Kaegi … Ten intramural investigators will receive exome sequencing data as part of their clinical research projects … NIH Clinical Center. Using CCGO funds, the NIH Intramural Sequencing Center will sequence the exomes of 1,000 NIH Clinical Center patients. Exome sequencing explores the 1-2 percent of the genome that codes …
Staff
Sangeetha Raghavan is a Senior Licensing and Patenting Manager in NHGRI's Technology Transfer Office.
… transfer professional with experience in evaluating technologies in wide ranging areas of biologics, diagnostics, … molecules and software. Her experience includes assessing technologies for their patentability and commercial … variety of intellectual property agreements, and marketing technologies to facilitate the transfer of such technologies …
News Release
Researchers developed a technique that will aid in a more accurate reconstruction of human genomes.
… a genome from the much smaller pieces of DNA that sequencing machines are able to read, much like putting … For example, the Angus breed evolved to produce a very high-quality beef product, while the Brahman breed, emerging … technology. The parents' genomes are first sequenced using high-accuracy short reads to determine which parts of their …